The mGluR7 allosteric agonist AMN082 produces antidepressant-like effects by modulating glutamatergic signaling

► AMPA receptors are involved in the behavioral effects of mGluR7 agonist AMN082 administration. ► AMN082-induced decreased of immobility in the tail suspension test is attenuated by NBQX. ► AMN082 alters the phosphorylation of GluR1, NR1, NR2b subunits in the hippocampus. ► mGluR7 activation could be an alternative to NMDARs blockers in the treatment of mood disorders.