Convolutamydine A and synthetic analogues have antinociceptive properties in mice

► Convolutamydine A and two analogues were evaluated in nociceptive models. ► Substances demonstrated peripheral antinociceptive effects. ► A supraspinal analgesic effect was observed in the hot plate model. ► The effects of convolutamydine A are mediated by all three systems. ► Analogues action involves the cholinergic and nitric oxide systems.