Lithium and valproate modulate energy metabolism in an animal model of mania induced by methamphetamine

► Li and VPA reversed m-AMPH-induced hyperactivity. ► Li and VPA reversed m-AMPH-induced energetic metabolism dysfunction. ► m-AMPH inhibited activities of Krebs cycle enzymes in all analyzed structures. ► m-AMPH inhibited activity complexes of mitochondrial respiratory chain. ► The effects of Li and VPA were dependent on the brain region analyzed.