Caffeine-induced taste aversions in Lewis and Fischer rat strains: Differential sensitivity to the aversive effects of drugs

► The LEW and F344 inbred rat strains differ in their reactivity to drugs of abuse. ► This study examined caffeine's ability to induce taste aversion in both strains. ► Caffeine induced strain-dependent taste aversion at 18 mg/kg. ► Caffeine increased activity in both strains with no strain differences. ► These data extend the range of drugs on which the LEW and F344 strains differ.