Repeated pre-exposure to tobacco smoke potentiates subsequent locomotor responses to nicotine and tobacco smoke but not amphetamine in adult rats

► Repeated exposure to tobacco smoke potentiates the locomotor response to smoke. ► Tobacco smoke exposure potentiates the locomotor response to nicotine. ► Tobacco smoke exposure induces tolerance to the depressant effects of nicotine. ► Tobacco smoke exposure does not affect the locomotor response to amphetamine.