Diacerein decreases visceral pain through inhibition of glutamatergic neurotransmission and cytokine signaling in mice

► Diacerein inhibits the nociception induced by acetic acid in mice. ► Diacerein exerts a systemic, spinal, supra-spinal and locally antinociceptive action. ► Inhibition of glutamate receptor contributes to the analgesic properties of diacerein. ► Antinociceptive diacerein effect depends on pro-inflammatory cytokine inhibition.