Agmatine, a metabolite of L-arginine, reverses scopolamine-induced learning and memory impairment in rats

► Agmatine did not alter cognitive performances in rats with normal memory status. ► Muscarinic antagonists have dissociable effects on memory processes in rats. ► Agmatine improved learning and memory in drug-induced models of dementia. ► Agmatine may have a modulator role in cognitive functions.