The analgesic activity and possible mechanisms of deacetyl asperulosidic acid methyl ester from Ji shi teng in mice

► Deacetyl Asperulosidic Acid Methyl Ester (DAAME) showed the antinociception. ► The possible analgesic mechanism involved in ATP sensitive K + channels. ► There was similar antinociception, but different mechanism between DAAME and PAME.