Antinociception induced by acute oral administration of sweet substance in young and adult rodents: The role of endogenous opioid peptides chemical mediators and μ1-opioid receptors

► Sweet substance-induce antinociception was evoked in young and adults rodents. ► Sucrose solution evoked antinociception by oral acute administration in Wistar rats. ► Endogenous opioid peptides are involved in antinociception induced by sucrose. ► µ1-opiod receptor is involved in sweet substance-induced antinociception.