Effects of sertraline on behavioral alterations caused by environmental enrichment and social isolation

► Environmental enrichment reduced stereotypy, improved the motor coordination. ► Rearing conditions did not affect anxiety and depression either in SC or EC. ► Sertraline reversed the effects of environmental enrichment on the stereotypy. ► It reduced the depression in EC and IC, but did not change in SC. ► Sertraline had anxiolytic effects in animals reared enriched conditions.