The antibiotic minocycline prevents methamphetamine-induced rewarding effects in mice

► Methamphetamine (METH) induced rewarding effects in rodents and humans. ► Minocycline blocked METH-induced rewarding effects in mice. ► Minocycline blocked METH-induced release of dopamine in nucleus accumbens. ► Minocycline may be a potential therapeutic drug for METH dependence.