Acetyl-l-carnitine and α-lipoic acid affect rotenone-induced damage in nigral dopaminergic neurons of rat brain, implication for Parkinson's disease therapy

► Rotenone affect nigral dopaminergic neurons in rats. ► Acetyl-L-carnitine or α-lipoic acid protected against neurotoxicity of rotenone. ► Combination of both agents gave a better response than single treatments.