Effects of noradrenergic denervation on L-DOPA-induced dyskinesia and its treatment by α- and β-adrenergic receptor antagonists in hemiparkinsonian rats

► Moderate NE loss reduces L-DOPA-induced dyskinesia and rotations. ► The α2-adrenergic antagonist idazoxan attenuates L-DOPA-induced dyskinesia. ► Propranolol, a b-adrenergic antagonist, reduces L-DOPA-induced dyskinesia. ► NE lesions do not alter anti-dyskinetic effects of adrenergic receptor antagonists.