Combined α7 nicotinic acetylcholine receptor agonism and partial serotonin transporter inhibition produce antidepressant-like effects in the mouse forced swim and tail suspension tests: A comparison of SSR180711 and PNU-282987

► α7 nicotinic receptor agonism enhances the effect of antidepressant drugs in mice. ► Behavioural and biochemical effects of SSR180711 and PNU-282987 were compared. ► SSR180711, but not PNU-282907, induced antidepressant-like effects in mice. ► Behaviourally effective doses of SSR180711 partially inhibited serotonin reuptake. ► SSR180711 represents the synergy of α7 nAChRs agonism and serotonin uptake inhibition.