Stimulation of the occipital or retrosplenial cortex reduces incision pain in rats

► Occipital cortex (OC) stimulation reduces incision pain for less than 10 min. ► Retrosplenial cortex (RSC) stimulation reduces incision pain for at least 15 min. ► Lidocaine into APtN reduced the effects of OC or RSC stimulation. ► Methysergide (Met) or naloxone (Nlx) into APtN reduced the effect of RSC stimulation. ► Met, Nlx or atropine into APtN did not change the effect of OC stimulation.