Chronic agomelatine and fluoxetine induce antidepressant-like effects in H/Rouen mice, a genetic mouse model of depression

► Agomelatine and fluoxetine as antidepressants. ► We examine preclinical evidence of antidepressant potential of these drugs. ► A novel genetic model of depression H/Rouen mice and anhedonia are chosen. ► Agomelatine is endowed with antidepressant-like properties in H/Rouen mice.