Behavioral and biochemical investigations to explore pharmacological potential of PPAR-gamma agonists in vascular dementia of diabetic rats

► Streptozotocin (STZ) diabetes induces endothelial dysfunction & vascular dementia. ► Diabetes increases serum glucose, oxidative stress, AChE activity & decrease NO. ► PPAR-γ agonists attenuated diabetic endothelial dysfunction & vascular dementia. ► PPAR-γ agonists attenuated diabetes induced impairment of biochemical levels. ► PPAR-γ agonists have shown good benefit in STZ diabetes induced vascular dementia.