Participation of brainstem monoaminergic nuclei in behavioral depression

► The role of central noradrenergic neurons in depression was reexamined in mice. ► Lesions with ivt DSP4 or DBH-SAP reduced depression and increased motor activity. ► Lesion effects were greatest with partial LC destruction plus damage to 5HT system. ► Results support a depressant behavioral role for brainstem monoaminergic neurons.