Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice

► Comparative study of modafinil, methamphetamine, and MDMA effects on mice behavior. ► Agonistic behavior of singly-housed males in interactions with group-housed partners. ► Effects of all tested drugs were distinct in predominantly timid and aggressive mice. ► Modafinil lowered timidity and enhanced aggression in timid mice. ► MDMA lowered aggression and increased sociability and timidity in aggressive mice.