Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: Involvement of adenosine and dopamine receptors

► We administered theacrine to rats to investigate locomotor activity. ► Motor stimulant effects of theacrine are mediated by actions in the NAc. ► Chronic administration didn't result in sensitization or tolerance. ► Theacrine represents a potential novel pharmacotherapeutic agent.