Evaluation of the behavioral and pharmacokinetic profile of SYA013, a homopiperazine analog of haloperidol in rats

► SYA013 inhibits d-amphetamine-induced locomotor hyperactivity in rats. ► SYA013 inhibits CAR in a dose dependent manner without escape failure responses. ► SYA013 has a log BB of 1.48 suggesting it readily crosses the BBB. ► WAY100,635 did not have a significant effect on the lack of catalepsy. ► 5HT1A receptor does not contribute significantly to the pharmacological profile.