Antidepressant-like effects of Δ9-tetrahydrocannabinol and rimonabant in the olfactory bulbectomised rat model of depression

► Antidepressant-like behavioural properties of both THC and rimonabant in OB rats. ► In intact rats THC increased BDNF but rimonabant had no effect. ► In intact rats rimonabant and THC increased the levels of p-ERKs1/2. ► Neither THC nor rimonabant altered expression of BDNF or pERK in the OB rats.