Synergistic anti-allodynic effects of nociceptin/orphanin FQ and cannabinoid systems in neuropathic mice

► Combinations of analgesics are commonly used in the management of chronic pain. ► Synergistic effects of nociceptin/orphanin FQ and cannabinoid systems are examined. ► Both JTC-801 and WIN 55,212-2 produced dose-dependent anti-allodynic effects. ► Co-administration of these drugs resulted in a synergistic interaction. ► This combination may have utility in neuropathic pain pharmacotherapy.