Infusions of neuropeptide Y into the lateral septum reduce anxiety-related behaviors in the rat

► Infusions of NPY into the lateral septum reduced neophagia and shock-probe burying. ► The effects of NPY on neophagia were blocked by the Y1 antagonist BIBO 3304. ► BIBO 3304 failed to block the effects of NPY on burying. ► Anxiolytic actions of lateral septal NPY might involve multiple Y receptor types.