Melatonin protects against neurobehavioral and mitochondrial deficits in a chronic mouse model of Parkinson's disease

► The chronic Parkinson's mice show neurobehavioral and mitochondrial deficits. ► Chronic melatonin treatment fully protects against mitochondrial dysfunction. ► Chronic melatonin also moderately prevents neurobehavioral deficits. ► Melatonin slows down the progression of Parkinson's like disorder in mice.