Subeffective doses of nitroparacetamol (NCX-701) enhance the antinociceptive activity of the α2-adrenoceptor agonist medetomidine

► The α2-adrenoceptor agonist medetomidine induces analgesia in inflammation. ► The antinociception induced by medetomidine was enhanced by low doses of NCX701. ► The ID50 and inhibitory doses of medetomidine were significantly reduced by NCX701. ► The duration of medetomidine-induced antinociception was significantly enlarged by NCX701.