Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats

► Curcumin interacts with valproate, phenytoin, phenobarbitone and carbamazepine. ► Curcumin with lower dose of antiepileptic drugs (AEDs) enhanced seizure protection. ► Curcumin with AEDs in their sub-therapeutic doses prevented cognitive impairment. ► Curcumin reversed the oxidative stress due to seizures. ► Curcumin can be used as an adjunct to these AEDs in epilepsy.