Ethanol-induced changes in the expression of proteins related to neurotransmission and metabolism in different regions of the rat brain

► Rats exposed to vaporized ethanol for 26 weeks attained blood levels of 450 mg%. ► Six brain regions were micro-dissected and submitted to proteomic investigation. ► Findings support a disrupted frontocerebellar circuitry following ethanol exposure. ► Findings also support regionally non-selective metabolic compromise.