Nicotine-induced conditioned place preference in adolescent rats

► Adolescent female rats revealed nicotine-induced CPP at a low dose of 0.03 mg/kg s.c. ► Same age adolescent male rats also showed nicotine-induced CPP at this same low dose. ► Nicotine-induced CPP lasted for three weeks with no further nicotine treatment. ► Results suggest that adolescent girls may be vulnerable to low levels of nicotine. ► In contrast with reports from human studies adolescent boys may share this sensitivity.