Differential modulatory actions of GABAA agonists on susceptibility to GABAA antagonists-induced seizures in morphine dependent rats: Possible mechanisms in seizure propensity

► Morphine changes the GABAA receptors response to its agonists and its antagonists. ► Morphine dependency has more positive effect on BIC than PTZ -induced seizures. ► Morphine pro-convulsant effect completely abolished by MUS than THIP.