Pharmacological and parametrical investigation of prepulse inhibition of startle and prepulse elicited reactions in Wistar rats

► Prepulse inhibition (PPI) as a model of sensorimotor gating. ► Drug-effects on parametric variations of PPI and reaction to the prepulse. ► Regulation of PPI by dopamine, cannabinoid and glutamate systems. ► Drug-effects on PPI and response to prepulse are unrelated.