Monosodium iodoacetate-induced osteoarthritis produces pain-depressed wheel running in rats: Implications for preclinical behavioral assessment of chronic pain

► Monosodium iodoacetate (MIA)-induced osteoarthritis depresses wheel running in rats. ► MIA is differentially potent across qualitatively different behavioral assays. ► MIA produces apparent rate-dependent effects in the assay of wheel running.