D-cycloserine selectively decreases nicotine self-administration in rats with low baseline levels of response

► Expanding the variety of treatments will aid tailored therapy for smoking cessation. ► Acute D-cycloserine decreased nicotine intake in low baseline rats. ► Acute D-cycloserine increased nicotine intake in high baseline rats. ► Chronic D-cycloserine selectively decreased nicotine intake in low baseline rats.