Additive effects of cannabinoid CB1 receptors blockade and cholecystokinin on feeding inhibition

► SR141716A activates c-Fos expression in brainstem areas receiving vagal inputs ·SR141716A has additive effects on CCK-induced feeding suppression in vivo. ► CB1 agonism counteracts the feeding suppression induced by CCK in vivo. ► Lorglumide pretreatment does not modify the anorectic effects of CB1 antagonism. ► CB1 antagonism inhibits feeding by mechanisms that do not involve CCK1 receptors.