Tamoxifen effects on respiratory chain complexes and creatine kinase activities in an animal model of mania

► Metabolism impairment and abnormal PKC activity are involved in bipolar disorder. ► TMX is a PKC inhibitor and interacts with mitochondrial respiratory chain. ► In an animal model of mania TMX decreases locomotor activity. ► TMX changes energetic metabolism parameters in parallel with behavioral changes. ► Inhibitors of PKC may act as a possible target for new medications to BD.