Fluoxetine prevents 8-OH-DPAT-induced hyperphagia in Fischer inbred rats

► Ovariectomized Fischer inbred rats failed to show anorexia in response to 5 mg/kg fluoxetine. ► This dose of fluoxetine prevented the hyperphagia due to 0.25 mg/kg 8-OH-DPAT. ► Ovariectomized rats with estradiol benzoate and progesterone priming did not differ from ovariectomized rats without hormonal priming.