SB-334867-A, a selective orexin-1 receptor antagonist, enhances taste aversion learning and blocks taste preference learning in rats

► SB-334867-A blocks saccharin-induced flavor preference. ► SB-334867-A does not impair LiCl-induced taste aversion learning (TAL). ► SB-334867-A did not induce TAL or reduce intake when administered without LiCl. ► Orexin may reinforce the association between gustatory and postingestive signals. ► Orexinergic system interventions allow study of the role of the LH in taste learning.