Role of dopamine D1- and D2-like receptor mechanisms in drug-seeking following methamphetamine self-administration in rats

► Dopamine D1- and D2-like receptors are implicated in reinstatement of drug-seeking. ► D1- and D2-like receptor mechanisms in methamphetamine reinstatement were investigated. ► Dopamine agonists reinstated methamphetamine-seeking. ► A D1 antagonist, but not a D2 antagonist, attenuated methamphetamine-seeking. ► Different from other drugs, indicating methamphetamine reinstatement is qualitatively dissimilar.