Spatiotemporal properties of locomotor activity after administration of central nervous stimulants and sedatives in mice

► Central sedatives and stimulants affect locomotor spatiotemporal properties. ► Pentobarbital and diazepam increase peripheral locomotion in an open field. ► Theophylline and caffeine increase central locomotion in an open field. ► Dose of CNS drugs also affects spatiotemporal properties of locomotion.