Gait analysis and pain response of two rodent models of osteoarthritis

► ACLT + pMMx and MIA rat models of osteoarthritis were evaluated in a short term study. ► ACLT + pMMx model showed no changes in gait parameters and allodynia. ► MIA is a more appropriate model for the evaluation of pain since. ► Significant changes in the dynamic gait parameters and allodynia was detected. ► And CGRP and substance P were increased in the lumbar spinal cord.