Pharmacological interaction between oxcarbazepine and two COX inhibitors in a rat model of inflammatory hyperalgesia

► Oxcarbazepine exerts a synergistic interaction with ibuprofen in inflammatory pain. ► The reduction of doses of both drugs which exert synergistic interaction is 4-fold. ► In contrast, oxcarbazepine exerts an additive interaction with etodolac. ► Our results might improve the treatment of inflammatory pain.