کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10838373 | 1067162 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antidepressant-like and antinociceptive-like actions of 4-(4â²-chlorophenyl)-6-(4â³-methylphenyl)-2-hydrazinepyrimidine Mannich base in mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Antidepressant-like and antinociceptive-like actions of 4-(4â²-chlorophenyl)-6-(4â³-methylphenyl)-2-hydrazinepyrimidine Mannich base in mice Antidepressant-like and antinociceptive-like actions of 4-(4â²-chlorophenyl)-6-(4â³-methylphenyl)-2-hydrazinepyrimidine Mannich base in mice](/preview/png/10838373.png)
چکیده انگلیسی
This study investigated the possible antidepressant and antinociceptive action of CPMPH Mannich base, as well as the involvement of serotonergic, dopaminergic, noradrenergic and opioid systems and the l-arginine-nitric oxide pathway in the antidepressant-like effect of CPMPH in the forced swimming test (FST) in mice. The immobility time in the FST was significantly reduced by CPMPH (0.1-10 mg/kg, i.p.), without accompanying changes in the ambulation in an open-field. CPMPH at high doses (i.p. or s.c. routes) produced a significant inhibition of acetic acid-induced writhing. The antidepressant-like effect of CPMPH (1 mg/kg, i.p.) in the FST was prevented by pre-treatment of mice with methysergide (2 mg/kg, i.p., a non-selective serotonin receptor antagonist), sulpiride (32 mg/kg, i.p., a D2 receptor antagonist) or yohimbine (1 mg/kg, i.p., an α2-adrenoceptor antagonist). In contrast, the antidepressant-like effect of CPMPH was not affected by pre-treatment (i.p.) with naloxone (1 mg/kg, a non-selective opioid receptor antagonist) or l-arginine (750 mg/kg, a nitric oxide precursor). The results demonstrate that CPMPH had an antidepressant-like action that appears to be mediated through its interaction with serotonergic, dopaminergic and noradrenergic systems.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 82, Issue 1, September 2005, Pages 156-162
Journal: Pharmacology Biochemistry and Behavior - Volume 82, Issue 1, September 2005, Pages 156-162
نویسندگان
A.L.S. Rodrigues, J.M. Rosa, V.M. Gadotti, E.C. Goulart, M.M. Santos, A.V. Silva, B. Sehnem, L.S. Rosa, R.M. Gonçalves, R. Corrêa, A.R.S. Santos,