کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10838423 1067167 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Autonomic efferents affect intake of imbalanced amino acid diets by rats
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Autonomic efferents affect intake of imbalanced amino acid diets by rats
چکیده انگلیسی
An anorectic response occurs following ingestion of imbalanced amino acid (IMB) diets. There are three phases o this response: 1, recognition of the IMB diet; 2, conditioned development of an aversion to the IMB diet; and 3, adaptation. Blockade of peripheral serotonin-3 (5-HT3) receptors or vagotomy attenuates Phase 2 of the anorectic response. We investigated whether sympathetic efferents interact with the ventral gastric branch (VGB), by cutting it (X), or with the 5-HT3 receptor in these responses. First, VGBX and sham-operated (SHAM) groups were injected with vehicle or phenoxybenzamine (α-blocker), or nadolol (β-blocker) before introducing the IMB diet. At 3 h suppression of the IMB diet ingestion was unchanged, showing no sympathetic efferent effect on Phase 1. Intake of the IMB diet increased 12-24 h later only in the SHAM + phenoxybenzamine group, so the VGB was necessary for α-blockade to enhance IMB diet intake during Phase 2 or possibly Phase 3. On days 2-5, intakes by the SHAM + phenoxybenzamine, VGBX + phenoxybenzamine and VGBX + nadolol groups were elevated. Therefore, α-blockade enhanced adaptation alone, but VGBX was necessary for β-receptor blockade to augment Phase 3 adaptation. Both sympathetic efferents and the VGB are involved in Phases 2-3. Second, rats received vehicle or nadolol or scopolamine (nonselective muscarinic blocker) or pirenzepine (muscarinic M-1 receptor blocker), w+/− tropisetron (5-HT3 blocker). Pirenzepine attenuated the tropisetron effect between 6-9 h, but then pirenzepine and nadolol enhanced the tropisetron effect between 9-12 h. Scopolamine attenuated the tropisetron effect between 9-12 h. While neither experiment showed effects during the recognition phase, the autonomic and serotonergic systems interact in the learned and adaptive responses to IMB diets.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 81, Issue 1, May 2005, Pages 24-31
نویسندگان
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