کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10838567 | 1067171 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Behavioral characterization of morphine effects on motor activity in mice
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Behavioral characterization of morphine effects on motor activity in mice Behavioral characterization of morphine effects on motor activity in mice](/preview/png/10838567.png)
چکیده انگلیسی
A biphasic effect of morphine on locomotion has been extensively described. Nevertheless, the effects of this opioid on other behavioral parameters have been overlooked. The aim of the present study was to verify the effects of different doses of morphine on motor behaviors observed in an open-field. Adult female mice were injected with saline or morphine (10, 15 and 20 mg/kg, i.p.) and observed in an open-field for quantification of locomotor and rearing frequencies as well as duration of immobility and grooming. The lowest dose of morphine decreased locomotion (and increased immobility duration) while the highest dose increased it. All doses tested decreased rearing and grooming. Thus, the effects of morphine on locomotion do not parallel to its effects on rearing and grooming. Our results indicate that locomotion not always reflects the effect of drugs on motor activity, which can be better investigated when other behavioral parameters are concomitantly taken into account.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 81, Issue 4, August 2005, Pages 923-927
Journal: Pharmacology Biochemistry and Behavior - Volume 81, Issue 4, August 2005, Pages 923-927
نویسندگان
Camilla L. Patti, Roberto Frussa-Filho, Regina H. Silva, Rita C. Carvalho, Sonia R. Kameda, André L. Takatsu-Coleman, Jaime L.S. Cunha, Vanessa C. AbÃlio,