Regulation of plant cytosolic aldolase functions by redox-modifications

► Multiple cysteine modifications in plant cytosolic aldolase. ► S-glutathionylation and S-nitrosylation leads to reversible inactivation. ► Cysteine modifications and inactivation are reversed by reduced thioredoxin. ► Aldolase and thioredoxin are nuclear-localized in isolated mesophyll protoplasts.