Vasoactive intestinal peptide re-balances TREM-1/TREM-2 ratio in acute lung injury

► We determined the expressions of TREM in the lung tissues of LPS-treated mice. ► We determined the expressions of TREM-1 and TREM-2 mRNA in various lung cells. ► We observed the TREM-1/TREM-2 ratio and presumed the effect on acute lung injury. ► We determined effects of VIP on expressions of the TREM in LPS-treated lung cells.