Neuroprotective properties of l-carnosine in the brain slices exposed to autoblood in the hemorrhagic stroke model in vitro

► We model hemorrhagic stroke in vitro on olfactory cortex slices of hypertensive rats. ► We use electrophysiologic recordings to analyze basal glutamatergic and GABABergic synaptic transmission. ► Autoblood blocks synaptic transmission in neurons of brain slices. ► l-carnosine pretreatment of slices may rescue the mechanisms of synaptic plasticity being inhibited by autoblood exposure. ► l-carnosine attenuates edema in olfactory cortex by improving function of glutamate receptors.