کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10845844 | 1069876 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tissue homeostasis and the control of the neoplastic phenotype in epithelial cancers
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Tissue homeostasis and the control of the neoplastic phenotype in epithelial cancers Tissue homeostasis and the control of the neoplastic phenotype in epithelial cancers](/preview/png/10845844.png)
چکیده انگلیسی
Neoplastic cells at various stages of tumor progression may remain dormant for many years. The suppression of the neoplastic phenotype and tumor outgrowth depends on close contact of neoplastic cells with surrounding normal cells. This review examines the nature of these contacts primarily in models for skin cancer induction. Junctional complexes, membrane associated growth factors and their receptors, and paracrine mechanisms likely contribute to this state of tumor cell dormancy. Understanding these mechanisms will be important in primary cancer prevention and for counteracting recurrences in cancer survivors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cancer Biology - Volume 15, Issue 2, April 2005, Pages 75-83
Journal: Seminars in Cancer Biology - Volume 15, Issue 2, April 2005, Pages 75-83
نویسندگان
Adam B. Glick, Stuart H. Yuspa,