کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10845848 1069876 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expanding fields of genetically altered cells in head and neck squamous carcinogenesis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Expanding fields of genetically altered cells in head and neck squamous carcinogenesis
چکیده انگلیسی
Recent molecular pathology studies in head and neck cancer support a carcinogenesis model in which the development of a field with genetically altered cells plays a central role. This preneoplastic field is of monoclonal origin and expands non-invasively superseding normal epithelium. Clonal divergence and selection within the field ultimately leads to the development of cancer. These fields can be large (over 7 cm diameter) and are often not visible for the surgeon explaining that they may remain after resection of the primary tumor. When not removed, a field is an important risk factor for secondary cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cancer Biology - Volume 15, Issue 2, April 2005, Pages 113-120
نویسندگان
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