Glucocorticoid receptor concentration and the ability to dimerize influence nuclear translocation and distribution

► The observed rate of nuclear import increases at higher GR concentrations. ► Loss of dimerization results in a decrease in the observed rate of nuclear import. ► Loss of dimerization results in a decreased extent of GR nuclear localization. ► The rate of nuclear export increases at low GR concentrations. ► The rate of nuclear export increases when GR dimerization is abrogated.